Effect of Orlistat on serum Uric acid level in adults: A systematic review and meta-analysis of randomized controlled trials

Link to article at PubMed

Int J Clin Pract. 2021 Jul 29:e14674. doi: 10.1111/ijcp.14674. Online ahead of print.


OBJECTIVE: Hyperuricemia increases the risk of gout and cardiovascular diseases. Obesity increases the risk of hyperuricemia while weight loss (>5 kg) has been reported to decrease urate. The effects of orlistat on serum uric acid are still controversial. The aim of this meta-analysis was to evaluate the influence of orlistat on serum uric acid levels in adults.

METHODS: Relevant studies, published up to May 2020, were searched systematically through PubMed/Medline, Scopus, and Google Scholar. All relevant randomized controlled clinical trials were included. Meta-analysis was performed using random-effect model. Subgroup analysis, sensitivity analysis, and meta-regression were also carried out RESULTS: Overall 7 trials (9 datasets) that enrolled 1786 subjects were included. Orlistat showed in a significant change in serum uric acid level (Difference in means: -17.661μmol, 95% CI: -31.615 to -3.707, P=0.01). A low heterogeneity observed across the studies (I2 = 25.119%). After categorizing studies on the basis of duration and sample size the effect of orlistat on serum uric acid was significant. The results of meta-regression were showed that significant relationships were not found between orlistat and serum uric acid in the duration of intervention.

CONCLUSION: We found a significant reduction in serum uric acid following orlistat therapy in adults.

PMID:34324762 | DOI:10.1111/ijcp.14674

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