Bexagliflozin for type 2 Diabetes: an overview of the data

Link to article at PubMed

Expert Opin Pharmacother. 2021 Jul 22. doi: 10.1080/14656566.2021.1959915. Online ahead of print.


INTRODUCTION: Sodium-glucose cotransporter-2 (SGLT2) inhibitors are a relatively novel glucose-lowering drugs (GLDs) which additionally promote weight loss and blood pressure reduction amongst other beneficial effects.

AREAS COVERED: This review reflects on the extra-glycaemic effects of SGLT2 inhibitors and their impact on important clinical endpoints, and provides an overview of data relating to a newer member of the SGLT2 inhibitor class, bexagliflozin.

EXPERT OPINION: SGLT2 inhibitors, while consolidating glycaemic control as adjunctive therapy, indisputably effect cardio-renal benefits in the T2D population which is prevalently afflicted by heightened cardiovascular risk profiles and a disproportionately increased incidence of unfavourable cardiovascular and renal clinical outcomes. The data from landmark trials demonstrate that beneficial effects of SGLT2 inhibitors extend to non-diabetic patients with chronic kidney disease (CKD) and/or heart failure with reduced ejection fraction (HFrEF). Preliminary findings from the BEST trial suggest that Bexagliflozin's effects reflect those of other licensed drugs in its class. Bexagliflozin has also been shown to be safe and effective in patients with diabetes and CKD stage 3b. If and when approved, it presents physicians with the prospect of an additional therapeutic option in managing patients with type 2 diabetes mellitus (T2D), and conceivably also, nondiabetic patients with established CKD and/or HFrEF.

PMID:34292100 | DOI:10.1080/14656566.2021.1959915

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