J Med Virol. 2021 Jul 21. doi: 10.1002/jmv.27218. Online ahead of print.
AIM: Both SARS-COV-2 and influenza viruses cause similar clinical presentations. It is essential to assess severely ill patients presenting with a viral syndrome for diagnostic and prognostic purposes. We aimed to compare clinical and biochemical features between pneumonia patients with COVID-19 and H1N1 METHOD: Sixty patients diagnosed with COVID-19 pneumonia and 61 patients diagnosed with influenza pneumonia hospitalized between October 2020- January 2021 and October 2017- December 2019 respectively. All the clinical data and laboratory results, Chest Computed Tomography(CT) scans, intensive care unit (ICU) admission, invasive mechanical ventilation (IMV), and outcomes were retrospectively evaluated.
RESULTS: The median age was 65 (range 32-96) years for patients with a COVID-19 diagnosis and 58 (range 18-83) years for patients with influenza (p= 0,002). Comorbidity index was significantly higher in COVID-19 patients. (p=0,010). DM and HT were statistically significantly more common in COVID-19 patients. (p:0,019, p: 0,008 respectively). Distribution of severe disease and mortality was not significantly different among COVID-19 patients than influenza patients.(p:0,096, p= 0,049).). In comparison to inflammation markers; CRP levels were significantly higher in influenza patients than COVID-19 patients. (p= 0,033). The presence of sputum was predictive for influenza (OR 0,342[95% CI, 2.1,130-0,899]). CRP and platelet were also predictive for COVID-19 (OR 4.764 [95% CI, 1,003-1,012] and OR 0,991 [95% CI 0,984-0,998] respectively.
CONCLUSION: We conclude that sputum symptom by itself much more detected in influenza patients. Besides that lower CRP and higher PLT count would be discriminative for COVID-19. This article is protected by copyright. All rights reserved.