“Vitamin D supplementation and COVID-19 treatment: A systematic review and meta-analysis”

Link to article at PubMed

Diabetes Metab Syndr. 2021 Jun 28;15(4):102189. doi: 10.1016/j.dsx.2021.102189. Online ahead of print.


BACKGROUND: Vitamin-D is an immune-modulator which might be linked to disease severity by SARS-CoV-2.

METHODS: Meta-analysis of RCTs and quasi-experimental studies, evaluating the role of vitamin-D supplementation in COVID patients was done.

RESULTS: Total 5 studies (3 RCTs and 2 Quasi-experimental) including n = 467 patients were included. Vitamin D didn't reduce mortality (RR 0.55, 95%CI 0.22 to 1.39, p = 0.21), ICU admission rates (RR 0.20, 95% CI 0.01-4.26, p = 0.3) and need for invasive ventilation (RR 0.24, 95% CI 0.01-7.89, p = 0.42).

CONCLUSION: No significant difference with vitamin-D supplementation on major health related outcomes in COVID-19. Well-designed RCTs are required addressing this topic.

PMID:34217144 | DOI:10.1016/j.dsx.2021.102189

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