The use of remdesivir for the management of patients with moderate-to-severe COVID-19: A systematic review

Link to article at PubMed

Expert Rev Anti Infect Ther. 2021 Jun 30. doi: 10.1080/14787210.2021.1949984. Online ahead of print.


Objective: We systematically reviewed the evidence of published original research to determine the role of remdesivir in the management of COVID-19 patients with a moderate-to-severe course of illness. Methods: A systematic search of articles was conducted in scientific databases, with the last update in May 2021. This paper systematically reviewed the clinical evidence available (randomized controlled trials, compassionate use studies, and case reports) on the use of remdesivir for patients with moderate or severe COVID-19. Results: A total of eleven studies were included: four studies based on compassionate use of remdesivir, three randomized, double-blind, placebo-controlled, multicentre trials, three randomized, open-label, phase III trials, and one case report. Clinical improvement and mortality rates in patients who used remdesivir varied across studies. Conclusion: Given the current evidence, there is insufficient data to confidently recommend the use of remdesivir alone for the treatment of adult hospitalized patients with moderate-to-severe COVID-19. However, remdesivir may be considered along with an anti-inflammatory agent in patients with or without pneumonia, on oxygen support, provided there is close monitoring of clinical and laboratory parameters and adverse events.

PMID:34192469 | DOI:10.1080/14787210.2021.1949984

Leave a Reply

Your email address will not be published.