Hepatology. 2021 May 18. doi: 10.1002/hep.31908. Online ahead of print.
Albumin is a globular, multifunctional protein that is highly conserved in nature. Alpha-fetoprotein, Vitamin D and E binding proteins are part of the albumin family and these are produced exclusively in the liver. Albumin is negatively charged and this gives it the oncotic properties it is well known for. More recently, it has become clear that albumin has clinically significant effects on antioxidant status, immune and endothelial function, capillary permeability, organ function, and metabolic homeostasis.