Three is a crowd: Clinical outcomes of a twice daily versus a thrice daily metronidazole dosing strategy from a multicenter study

Link to article at PubMed

Anaerobe. 2021 May 6:102378. doi: 10.1016/j.anaerobe.2021.102378. Online ahead of print.


This was a multicenter, retrospective study of patients with anaerobic bacteremia comparing metronidazole 500mg every 8 hours versus 500mg every 12 hours. Of 782 patients reviewed, 85 met inclusion criteria. There was no significant difference in mortality, length of stay, or escalation of therapy between dosing strategies.

PMID:33965559 | DOI:10.1016/j.anaerobe.2021.102378

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