Therapeutic Approaches for SARS-CoV-2 Infection

Link to article at PubMed

Methods. 2021 May 4:S1046-2023(21)00126-2. doi: 10.1016/j.ymeth.2021.04.026. Online ahead of print.


Therapeutic approaches to COVID-19 treatment leverage on crucial target proteins of SARS-CoV-2 replication machinery. It's been approximately 12 months of pandemic and yet there is no known specific drugs are available. However, research is progressing with time in terms of high throughput virtual screening (HTVS) and rational design of repurposed, novel synthetic and natural products drug discovery by understanding the viral life cycle, immuno-pathological and clinical outcomes in patients based on host's nutritional, metabolic and lifestyle status. Further, complementary and integrative health approaches (CIHA) have also shown to improve the resiliency and immune responses among people. In this article, we summarize about all the therapeutic approaches for COVID-19 antiviral drug discovery including computer aided virtual screening, repurposed drugs, immunomodulators, vaccines, plasma therapy, miscellaneous adjunct therapies and phage technology to unravel insightful mechanistic pathways of targeting SARS-CoV-2 and host's intrinsic innate immunity at various checkpoints that aid in the containment of the disease.

PMID:33962011 | DOI:10.1016/j.ymeth.2021.04.026

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