Half-year follow-up of patients recovering from severe COVID-19: Analysis of symptoms and their risk factors

Link to article at PubMed

J Intern Med. 2021 Apr 27. doi: 10.1111/joim.13284. Online ahead of print.


OBJECTIVES: To understand the sequelae of COVID-19.

METHODS: We followed up 1174 patients with severe coronavirus disease 2019 (COVID-19)who were recovered and discharged for 6 months.

RESULTS: There were 175 cases with clear IgG results 6 months after discharge, of which 82 (46.9%) were IgG (+) and 16 (9.1%) were IgG (dim+). Four hundred and forty-one participants (55.4%) had some kind of sequelae. The most common symptoms were fatigue (25.3%), sleep disorder (23.2%) and shortness of breath (20.4%). In those who had sequelae, 262 (59.4%) had more than one symptom. Critical cases were more likely to have cough (20.5% vs 11.6%, p = 0.023) and hypomnesis (15.1% vs 8.0%, p = 0.041) than severe cases. Furthermore, univariate and multivariate logistic regression analyses revealed that women are more likely to have multiple symptoms (p = 0.002), fatigue (p = 0.009) and sleep disorder (p = 0.008), whereas critical illness was found as independent risk factor for hypomnesis (p = 0.045).

CONCLUSION: Our study demonstrated the duration of antibody and sequelae of COVID-19 and compared the differences amongst different populations.

PMID:33904618 | DOI:10.1111/joim.13284

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