The effect of midodrine on lactate clearance in patients with septic shock: a pilot study

Link to article at PubMed

J Comp Eff Res. 2021 Apr 16. doi: 10.2217/cer-2020-0238. Online ahead of print.

ABSTRACT

Background: The effect of midodrine on lactate clearance has not been assessed in critically ill patients yet. Objective: The goal of this study was to assess the effect of adjunctive midodrine therapy on lactate clearance in patients with septic shock. Materials & methods: Patients with septic shock were assigned to receive either adjunctive midodrine 10 mg three-times a day for 5 days (midodrine group = 15 patients) or not (control group = 13 patients). Results: The lactate clearance was significantly faster in the midodrine group than the control group (p = 0.049) with a large effect size ( = 0.141). Conclusion: When midodrine was added to intravenous vasopressors, it significantly accelerated lactate clearance in patients with septic shock. Trial registration number: IRCT20100228003449N25 (Clinicaltrials.gov).

PMID:33860672 | DOI:10.2217/cer-2020-0238

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