J Eur Acad Dermatol Venereol. 2021 Mar 30. doi: 10.1111/jdv.17250. Online ahead of print.
The coronavirus disease 2019 (COVID-19) has been associated to a wide clinical spectrum of skin manifestations, including chilblain-like, urticarial, vesicular, maculopapular, livedoid and vasculitic lesions, among others1,2 . However, the exact pathophysiology for the appearance of skin lesions is still unknown. Several hypotheses have been suggested, including viral hypersensitivity reactions, overexpression of type I interferons, COVID-19 induced coagulopathy, thrombotic microangiopathy and direct viral damage3-6 .