The Role of Renal Functional Reserve in Predicting Acute Kidney Injury

Link to article at PubMed

Crit Care Clin. 2021 Apr;37(2):399-407. doi: 10.1016/j.ccc.2020.11.008. Epub 2021 Feb 13.


Renal functional reserve (RFR) is described as the difference between a glomerular filtration rate (GFR) measured at baseline and after protein stimulation. The percent change in GFR after a protein load varies based on differences in experimental conditions, with the use of an oral meat protein stimulus and a creatinine clearance method to quantify GFR showing the greatest RFR. A decline in RFR has been found in numerous patient groups. Recent investigations have suggested that a lower RFR may be associated with an increased risk of acute kidney injury and eventual chronic kidney disease.

PMID:33752863 | DOI:10.1016/j.ccc.2020.11.008

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