Urea to albumin ratio is a predictor of mortality in patients with septic shock

Link to article at PubMed

Clin Nutr ESPEN. 2021 Apr;42:361-365. doi: 10.1016/j.clnesp.2021.01.007. Epub 2021 Feb 15.


BACKGROUND: The purpose of this study was to evaluate urea to albumin ratio (UAR) as predictor of mortality in patients with septic shock.

METHODS: We included all individuals aged ≥ 18 years, with the diagnosis of septic shock at Intensive Care Unit (ICU) admission. Laboratorial and clinical data was recorded within the first 24 h of the patient's admission. Serum urea and albumin concentration were used for UAR calculation. All patients were followed during their ICU stay and the mortality rate was recorded.

RESULTS: 222 patients were included in the analysis; the mean age was 62.3 ± 15.1 years and 66% were male. Mortality rate during the ICU stay was 59.9% and the median UAR was 40.7 (24.5-66.1). The UAR was also higher in patients who died in the ICU and was positively correlated with APACHE II, SOFA score and CRP. The ROC ICU mortality development (AUC: 0.617; CI 95%: 0.541-0.693; p: 0.003) at the cutoff of ≥47.25. Furthermore, UAR values were associated with ICU mortality when adjusted by age, sex and APACHE II (OR: 1.011; CI95%:1.000-1.022; p = 0.043) and when adjusted by lactate (OR: 1.014; CI95%:1.003-1.024; p = 0.009).

CONCLUSIONS: Our data suggest that UAR could play a role as predictor of ICU mortality in patients with septic shock.

PMID:33745606 | DOI:10.1016/j.clnesp.2021.01.007

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