Biosci Rep. 2021 Jan 22:BSR20203584. doi: 10.1042/BSR20203584. Online ahead of print.
BACKGROUND: Hyperglycaemia at admission has been demonstrated to exacerbate the outcomes of coronavirus disease 2019 (COVID-19) but a meta-analysis is lacking to further confirm this hypothesis. The purpose of this meta-analysis was to summarize the evidence on the association between hyperglycaemia at admission and the development of COVID-19.
METHOD: Four databases namely, PubMed, Web of Science, Embase and Cochrane Library, were screened for eligible studies. STATA software was utilized to pool data for this meta-analysis. The primary outcomes included mortality and severity. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated with random-effects models, and the quality of evidence was appraised by the Newcastle-Ottawa Scale (NOS). This meta-analysis was prospectively registered online on PROSPERO, CRD42020191763.
RESULTS: Sixteen observational studies with 6386 COVID-19 patients relating hyperglycaemia at admission to COVID-19 outcomes were included. The overall data demonstrated that, compared with the control, the hyperglycaemia at admission group was more likely to have increased mortality (OR = 3.45, 95% CI, 2.26-5.26) and severe/critical complications (OR = 2.08, 95% CI, 1.45-2.99) of COVID-19.
CONCLUSION: Hyperglycaemia at admission in COVID-19 patients may be a strong predictor of mortality and complications.