2021 Oct 10. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–.
Uremic encephalopathy (UE) is defined as cerebral dysfunction due to the accumulation of toxins resulting from acute or chronic renal failure. It usually develops in patients who are suffering from acute or chronic renal failure when their estimated glomerular filtration rate (eGFR) decreases and stays below 15 mL/min. The clinical presentation of UE is broad, varying from subtle to florid. The clinical course of UE is always progressive when untreated. UE is at least partially reversible with the initiation of renal replacement therapy. Therefore, UE is an indication to start renal replacement therapy.