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COVID-19 vaccines (tozinameran (BNT162b2) and mRNA-1273 SARS-CoV-2) received FDA emergency use authorized (EUA) to prevent COVID-19 caused by the SARS-CoV-2 virus. This activity reviews the indications, administration, and contraindications for COVID-19 vaccines: tozinameran (BNT162b2) and mRNA-1273 SARS-CoV-2. This activity will also highlight the mechanism of action, adverse event profile, and other key elements of the COVID-19 vaccines in the clinical setting for the interprofessional team members when vaccinating individuals to prevent COVID-19 and its related conditions sequelae.