J Med Virol. 2020 Dec 30. doi: 10.1002/jmv.26766. Online ahead of print.
OBJECTIVE: The objective of this study was to identify predictive factors of mortality in older adults with COVID-19, including the level of clinical frailty by using the Clinical Frailty Scale (CFS).
METHODS: We analyzed medical records of all patients aged of 75 and older with a confirmed diagnosis of COVID-19 hospitalized in our Hospital between March 3, 2020 and April 25, 2020. Standardized variables were prospectively collected, and standardized care were provided to all patients.
RESULTS: 186 patients were included (mean 85.3±5.78 y). The all cause 30-day mortality was 30% (56/186). At admission, dead patients were more dyspneic (57% vs 38%, p=0.014), had more often an oxygen saturation <94% (70% vs 47%, p<0.01) and had more often a heart rate faster than 90/min (70% vs 42%, p<0.001). Mortality increased in parallel with CFS score (p=0.051) (20 deaths (36%) in 7-9 category). In multivariate analysis, CFS score (OR= 1.49 CI (95%), 1.01-2.19, p=0.046), age (OR=1.15 CI 95% 1.01-1.31 p=0.034), and dyspnea (OR=5.37 CI 95% 1.33-21.68, p=0.018) were associated with all-cause 30-day mortality.
CONCLUSIONS: It is necessary to integrate the assessment of frailty to determine care management plan of older patients with COVID-19, rather than the only restrictive criterion of age. This article is protected by copyright. All rights reserved.