Morning serum cortisol is superior to salivary cortisone and cortisol in predicting normal adrenal function in suspected adrenal insufficiency

Link to article at PubMed

Clin Endocrinol (Oxf). 2020 Dec 8. doi: 10.1111/cen.14388. Online ahead of print.


A low index of suspicion for adrenal insufficiency (AI) is necessary to avoid catastrophic missed diagnoses. In consequence most short synacthen tests (SSTs), the first-line investigation in suspected adrenal insufficiency (AI), are normal since they mainly exclude AI. A SST is invasive, labour intensive and requires the patient to attend hospital for the test to be performed under supervision. Consequently, morning serum cortisol cut-offs have been derived to identify patients with an unequivocal pass or fail in a SST, thus reducing the need for SSTs.1.

PMID:33290598 | DOI:10.1111/cen.14388

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