High-Dose Methylprednisolone in Nonintubated Patients with Severe COVID-19 Pneumonia

Link to article at PubMed

Eur J Clin Invest. 2020 Nov 20:e13458. doi: 10.1111/eci.13458. Online ahead of print.


BACKGROUND: Recent trials with dexamethasone and hydrocortisone have demonstrated benefit in patients with coronavirus disease 2019 (COVID-19). Data on methylprednisolone are limited.

METHODS: Retrospective cohort of consecutive adults with severe COVID-19 pneumonia on high-flow oxygen (FiO2 ≥50%) admitted to an academic center in New York, from March 1 to April 15, 2020. We used inverse probability of treatment weights to estimate the effect of methylprednisolone on clinical outcomes and intensive care resources utilization.

RESULTS: Of 447 patients, 153 (34.2%) received methylprednisolone and 294 (65.8%) received no corticosteroids. At 28 days, 102 patients (22.8%) had died and 115 (25.7%) received mechanical ventilation. In weighted analyses, risk for death or mechanical ventilation was 37% lower with methylprednisolone (hazard ratio 0.63; 95%CI 0.47-0.86; P=0.003), driven by less frequent mechanical ventilation (subhazard ratio 0.56; 95%CI 0.40-0.79; P=0.001); mortality did not differ between groups. The methylprednisolone group had 2.8 more ventilator-free days (95%CI 0.5-5.1; P=0.017) and 2.6 more intensive care-free days (95%CI 0.2-4.9; P=0.033) during the first 28 days. Complications rates were not higher with methylprednisolone.

CONCLUSIONS: In nonintubated patients with severe COVID-19 pneumonia, methylprednisolone was associated with reduced need for mechanical ventilation and less intensive care resources utilization without excess complications.

PMID:33219551 | DOI:10.1111/eci.13458

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