The beneficial and pathogenic roles of complement in COVID-19

Link to article at PubMed

Cleve Clin J Med. 2020 Oct 28:10.3949/ccjm.87a.ccc065. doi: 10.3949/ccjm.87a.ccc065. Online ahead of print.


We briefly summarize the complement system and its functions in immunity and disease. We present data supporting the requirement of complement to resolve COVID-19, and discuss how complement overactivation later in severe disease could drive multiorgan damage characteristic of fatal COVID-19.

PMID:33115882 | PMC:PMC8079550 | DOI:10.3949/ccjm.87a.ccc065

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