Cleve Clin J Med. 2020 Oct 28:10.3949/ccjm.87a.ccc065. doi: 10.3949/ccjm.87a.ccc065. Online ahead of print.
We briefly summarize the complement system and its functions in immunity and disease. We present data supporting the requirement of complement to resolve COVID-19, and discuss how complement overactivation later in severe disease could drive multiorgan damage characteristic of fatal COVID-19.