Oliceridine: First Approval

Link to article at PubMed

Drugs. 2020 Nov;80(16):1739-1744. doi: 10.1007/s40265-020-01414-9.


Oliceridine (Olinvyk™, Trevena, Inc.) is a novel μ opioid agonist that was recently approved in the USA for use in adults for the management of acute pain severe enough to require an intravenous opioid analgesic and for whom alternative treatments are inadequate. Unlike opioid agonists currently in use, the interaction of oliceridine with the opioid receptor is selective to the G protein pathway, with low potency for β-arrestin recruitment, which may lead to fewer opioid-related adverse events. This article summarizes the milestones in the development of oliceridine leading to this first approval.

PMID:33025536 | DOI:10.1007/s40265-020-01414-9

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