Time to antibiotic administration and patient outcomes in community-acquired pneumonia: results from a prospective cohort study

Link to article at PubMed

Clin Microbiol Infect. 2020 Sep 4:S1198-743X(20)30520-6. doi: 10.1016/j.cmi.2020.08.037. Online ahead of print.


OBJECTIVES: Community-acquired pneumonia (CAP) is a frequently occurring disease, linked to high mortality and morbidity. Previous studies indicated that the administration of antibiotics within 4 hours of admission can improve key patient outcomes associated with CAP, such as mortality and time to clinical stability. However, the results have been heterogeneous and may not be applicable to all healthcare settings. Therefore, we designed a cohort study to estimate the impact of timely antibiotic administration on outcomes in patients admitted with CAP.

METHODS: he impact of antibiotic administration within 4 hours of admission and other covariates were estimated for 30-day mortality, stability within 72 hours, 30-day readmission and time to discharge, using multivariable regression models. Sensitivity analyses were performed on a subset of patients with the most severe CAP and a propensity score matched cohort.

RESULTS: In total, 2,264 patients were included. Of these, 273 (12.1%) died within 30 days from admission, 1,277 (56.4%) were alive and stable within 72 hours and 334 (14.8%) were discharged alive and readmitted within 30 days. Median length of hospital stay was 5 days (interquartile range 3-8). In all models, the administration of antibiotics within 4 hours of admission had no significant effect on the outcomes. The adjusted odds ratios (OR) derived from the multivariable models for 30-day mortality, stability within 72 hours and 30-day readmission were 1.01 (95% confidence interval [CI] 0.76; 1.33), 0.88 (95% CI 0.74; 1.05) and 1.05 (95% CI 0.82; 1.34). The adjusted hazard ratio (HR) for time to discharge was 1.00 (95% CI 0.91; 1.10).

CONCLUSIONS: A strict 4-hour threshold for antibiotic administration in all patients admitted with CAP is not reasonable. Instead, our results suggested that patients should be triaged and prioritised according to age, comorbidities, clinical condition, and pneumonia severity.

PMID:32896655 | DOI:10.1016/j.cmi.2020.08.037

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