Effects of COVID-19 on the Nervous System

Link to article at PubMed

Cell. 2020 Aug 19:S0092-8674(20)31070-9. doi: 10.1016/j.cell.2020.08.028. Online ahead of print.


Neurological complications have emerged as a significant cause of morbidity and mortality in the ongoing COVID-19 pandemic. Beside respiratory insufficiency, many hospitalized patients exhibit neurological manifestations ranging from headache and loss of smell, to confusion and disabling strokes. COVID-19 is also anticipated to take a toll on the nervous system in the long term. Here, we will provide a critical appraisal of the potential for neurotropism and mechanisms of neuropathogenesis of SARS-CoV-2 as they relate to the acute and chronic neurological consequences of the infection. Finally, we will examine potential avenues for future research and therapeutic development.

PMID:32882182 | DOI:10.1016/j.cell.2020.08.028

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