Am J Transplant. 2020 Aug 26. doi: 10.1111/ajt.16280. Online ahead of print.
National data on patient characteristics, treatment, and outcomes of critically ill COVID-19 solid organ transplant(SOT) patients are limited. We analyzed data from a multicenter cohort study of adults with laboratory-confirmed COVID-19 admitted to intensive care units(ICUs) at 68 hospitals across the United States from March 4th to May 8th , 2020. From 4,153 patients, we created a propensity score matched cohort of 386 patients, including 98 SOT patients and 288 non-SOT patients. We used a binomial generalized linear model(log-binomial model) to examine the association of SOT status with death and other clinical outcomes. Among the 386 patients, the median age was 60 years, 72% were male, and 41% were black. Death within 28 days of ICU admission was similar in SOT and non-SOT patients(40% and 43%, respectively; relative risk[RR] 0.92 [95% Confidence Interval(CI):0.70-1.22]). Other outcomes and requirement for organ support including receipt of mechanical ventilation, development of acute respiratory distress syndrome, and receipt of vasopressors were also similar between groups. There was a trend toward higher risk of acute kidney injury requiring renal replacement therapy in SOT vs. non-SOT patients (37% vs. 27%; RR[95%CI]:1.34 [0.97-1.85]). Death and organ support requirement were similar between SOT and non-SOT critically ill patients with COVID-19.
PMID:32844546 | DOI:10.1111/ajt.16280