Risk factors for the COVID-19 severity and its correlation with viral shedding: a retrospective cohort study

Link to article at PubMed

J Med Virol. 2020 Jul 29. doi: 10.1002/jmv.26367. Online ahead of print.

ABSTRACT

BACKGROUND: Coronavirus disease 2019 (COVID-19) have become a pandemic in the world. This study is aim to explore risk factors for COVID-19 severity in the early stage and the correlation between the viral shedding and COVID-19 severity.

METHODS: We included inpatient with laboratory confirmed COVID-19 who had been discharged by Mar 9, 2020.The medical record data and dynamic change of biochemical indicators in-hospital were compared between common and severe patients.

RESULTS: 80 patients were included in this study. Multivariable regression demonstrated increasing odds of severity associated with the duration of fever (odds ratio 1.42, 95% CI 1.10-1.82, per day increase; p=0·007), CRP (1.26, 95% CI 1.04-1.52; p=0.02), and PO2 <80 mmHg (28.07, 95% CI 1.50-524.12; p=0.026) on admission. We found SARS-CoV-2 viral RNA could be long-term presence in respiratory tract and fecal sample, up to 43 and 46 days respectively. However, the duration of viral shedding have no correlation with the COVID-19 severity.

CONCLUSION: The duration of fever, elevated CRP and PO2 < 80 mmHg on admission were associated with the COVID-19 severity in the early stage and there is no correlation between the viral shedding and COVID-19 severity. This article is protected by copyright. All rights reserved.

PMID:32725915 | DOI:10.1002/jmv.26367

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