Lessons for COVID-19 Immunity from Other Coronavirus Infections

Link to article at PubMed

Immunity. 2020 Jul 14:S1074-7613(20)30312-5. doi: 10.1016/j.immuni.2020.07.005. Online ahead of print.

ABSTRACT

A key goal to controlling coronavirus disease 2019 (COVID-19) is developing an effective vaccine. Development of a vaccine requires knowledge of what constitutes a protective immune response and also features that might be pathogenic. Protective and pathogenic aspects of the response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not well understood, partly because the virus has infected humans for only 6 months. However, insight into coronavirus immunity can be informed by previous studies of immune responses to non-human coronaviruses, common cold coronaviruses, and SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV). Here, we review the literature describing these responses and discuss their relevance to the SARS-CoV-2 immune response.

PMID:32717182 | DOI:10.1016/j.immuni.2020.07.005

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