The use of hydroxychloroquine plus azithromycin and early hospital admission are beneficial in Covid-19 patients: Turkey experience with real-life data

Link to article at PubMed

Turk J Med Sci. 2020 Jul 19. doi: 10.3906/sag-2005-82. Online ahead of print.


AIM: New treatment regimens for COVID-19, which threatened the world recently, continue to be investigated. Although some of the treatments are promising, it is thought to be early to clearly state that there is definitive treatment. Experiences and treatment protocols studies coming from the centers are still very important. The aim of this study is to evaluate factors affecting the treatment process in the first cases followed in our clinic.

MATERIALS AND METHODS: The consecutive hospitalized patients with COVID-19 pneumonia were analyzed in this retrospective and cross-sectional study. Datas were recorded from the electronic and written files of patients.

RESULTS: Eighty three patients were evaluated. The median age was 50±15 years. Fourty eight (57.8%) patients had one or more comorbidities. The most common comorbidity was hypertension. The most common symptom was cough in 58 patients (70%). The overall mortality was 15% and 85% of the patients were discharged. The time between the onset of symptoms and hospitalization was statistically significantly longer in deceased patients (p=0,039). Age, D-Dimer, troponin, creatine kinase (CK), CK-MB, ferritin, procalcitonin, and neutrophil to lymphocyte ratio were statistically significantly higher in deceased patients than survivor patients. Performed subgroup analysis, in the patients receiving azithromycin plus hydroxychloroquine and other antibiotics plus hydroxychloroquine, the duration of hospitalization was shorter in azithromycin group (p=0,027).

CONCLUSION: Early treatment and early admission to the hospital can be crucial for the better treatment process. Combination therapy with azithromycin may be preferred in the first treatment choice because it can shorten the length of hospital stay.

PMID:32682360 | DOI:10.3906/sag-2005-82

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