Clinical characteristics, management and outcome of Covid-19-associated immune thrombocytopenia. A French multicenter series

Link to article at PubMed

Br J Haematol. 2020 Jul 17. doi: 10.1111/bjh.17024. Online ahead of print.


The causes of secondary immune thrombocytopenia (ITP), which account for approximately 18 to 20% of all adult ITP cases, include some viral infections (Cines et al, 2009; Moulis et al, 2014). Indeed, ITP can be triggered by or associated with many viruses including hepatitis C virus, human immunodeficiency virus, cytomegalovirus, Epstein-Barr virus and others like severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) (Boyer Chammard et al, 2017; Tanaka et al, 2003; Yang et al, 2005; Cines et al, 2009). Among the suspected mechanisms, antibodies directed against virus glycoproteins may cross-react with platelet surface integrins like GPIIb/IIIa or GPIb-IX-V (Assinger, 2014).

PMID:32678953 | DOI:10.1111/bjh.17024

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