Cytokine Storms: Understanding COVID-19

Link to article at PubMed

Mangalmurti N and Hunter CA. Immunity 2020 - Review.


The elevated circulating levels of cytokines associated with a variety of infectious and immune-mediated conditions are frequently termed a cytokine storm. Here, we explain the protective functions of cytokines in "ideal" responses; the multi-factorial origins that can drive these responses to become pathological; and how this ultimately leads to vascular damage, immunopathology, and worsening clinical outcomes.

PMID:32610079 | DOI:10.1016/j.immuni.2020.06.017

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