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Early administration of ritonavir-boosted lopinavir could prevent severe COVID-19.
J Infect. 2020 May 27;:
Authors: Klement-Frutos E, Burrel S, Peytavin G, Marot S, Lê MP, Godefroy N, Calvez V, Marcelin AG, Caumes E, Pourcher V, Boutolleau D
Abstract
No specific treatment against SARS-CoV-2 is available after 6 months of COVID-19 worldwide outbreak Antivirals could decrease the viral load and reduce direct and indirect damages of SARSCoV-2 infection Ritonavir-bosted lopinavir is effective against SARS-CoV-2 in vitro Sequential virological and pharmacological monitoring helped to understand the efficacy of ritonavir-boosted lopinavir in a SARS-CoV-2 infected patient Ritonavir-boosted lopinavir could be proposed as early treatment for SARS-CoV-2 infection.
PMID: 32473230 [PubMed - as supplied by publisher]