Neutrophil to Lymphocyte Ratio as Prognostic and Predictive Factor in Patients with Coronavirus Disease 2019: A Retrospective Cross-sectional Study.
J Med Virol. 2020 May 26;:
Authors: Yan X, Li F, Wang X, Yan J, Zhu F, Tang S, Deng Y, Wang H, Chen R, Yu Z, Li Y, Shang J, Zeng L, Zhao J, Guan C, Liu Q, Chen H, Gong W, Huang X, Zhang YJ, Liu J, Dong X, Zheng W, Nie S, Li D
OBJECTIVE: This retrospective study was designed to explore whether neutrophil to lymphocyte ratio (NLR) is a prognostic factor in patients with coronavirus disease 2019 (covid-19).
METHODS: A cohort of patients with covid-19 admitted to the Tongren Hospital of Wuhan University from January 11, 2020 to March 3, 2020 was retrospectively analyzed. Patients with hematologic malignancy were excluded. The NLR was calculated by dividing the neutrophil count by the lymphocyte count. NLR values were measured at the time of admission. The primary outcome was all-cause in-hospital mortality. A multivariate logistic analysis was performed.
RESULTS: 1004 patients with covid-19 were included in this study. The mortality rate was 4.0% (40 cases). The median age of nonsurvivors (68 years) was significantly older than survivors (62 years). Male sex was more predominant in nonsurvival group (27; 67.5%) than in the survival group (466; 48.3%). NLR value of nonsurvival group (median 49.06, IQR 25.71-69.70) was higher than that of survival group (median 4.11, IQR 2.44-8.12, P < 0.001). In multivariate logistic regression analysis, after adjusting for confounding factors, NLR > 11.75 was significantly correlated with all-cause in-hospital mortality (OR = 44.351, 95% CI = 4.627-425.088).
CONCLUSIONS: These results suggest that the NLR at hospital admission is associated in-hospital mortality among patients with covid-19. Therefore, the NLR appears to be a significant prognostic biomarker of outcomes in critically ill patients with covid-19. However, further investigation is needed to validate this relationship with data collected prospectively. This article is protected by copyright. All rights reserved.
PMID: 32458459 [PubMed - as supplied by publisher]