Hydroxychloroquine in COVID-19 patients: what still needs to be known about the kinetics.
Clin Infect Dis. 2020 May 11;:
Authors: Martin-Blondel G, Ruiz S, Murris M, Faguer S, Duhalde V, Eyvrard F, Izopet J, Mansuy JM, Rolland Y, Delavigne K, Guimbaud R, Pugnet G, Conil JM, Georges B, Delobel P, Minville V, Silva Sifontes S, Concordet D, Gandia P
Different dosage regimens of hydroxychloroquine are used to manage COVID-19 patients, without information on the pharmacokinetics in this population.Blood samples (n=101) were collected from 57 COVID-19 patients for 7 days and concentrations were compared with simulated kinetic profiles.Hydroxychloroquine exposure is low and cannot be predicted by other populations.
PMID: 32392332 [PubMed - as supplied by publisher]