Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential.

Link to article at PubMed

Icon for American Chemical Society Icon for PubMed Central Related Articles

Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential.

ACS Infect Dis. 2020 05 08;6(5):909-915

Authors: Xu J, Shi PY, Li H, Zhou J

Abstract
The recent outbreak of coronavirus disease 2019 (COVID-19) highlights an urgent need for therapeutics. Through a series of drug repurposing screening campaigns, niclosamide, an FDA-approved anthelminthic drug, was found to be effective against various viral infections with nanomolar to micromolar potency such as SARS-CoV, MERS-CoV, ZIKV, HCV, and human adenovirus, indicating its potential as an antiviral agent. In this brief review, we summarize the broad antiviral activity of niclosamide and highlight its potential clinical use in the treatment of COVID-19.

PMID: 32125140 [PubMed - indexed for MEDLINE]

Leave a Reply

Your email address will not be published.