COVID-19 gone bad: A new character in the spectrum of the hyperferritinemic syndrome?
Autoimmun Rev. 2020 May 05;:102573
Authors: Colafrancesco S, Alessandri C, Conti F, Priori R
The severe form of COVID-19 share several clinical and laboratory features with four entities gathered under the term "hyperferritinemic syndrome" and including macrophage activation syndrome (MAS), adult-onset Still's disease (AOSD), catastrophic anti-phospholipid syndrome (CAPS) and septic shock. COVID-19 systemic inflammatory reaction and "hyperferritinemic syndromes" are all characterized by high serum ferritin and a life-threatening hyper-inflammation sustained by a cytokines storm which eventually leads to multi-organ failure. In this review, we analyze the possible epidemiological and molecular mechanisms responsible for hyper-inflammation in patients with severe COVID-19 and we underline the similarities between this condition and "hyperferritinemic syndromes" which would allow considering this entity as the fifth member of the spectrum of inflammatory conditions.
PMID: 32387470 [PubMed - as supplied by publisher]