Association of Obesity with Disease Severity among Patients with COVID-19.
Obesity (Silver Spring). 2020 Apr 30;:
Authors: Kalligeros M, Shehadeh F, Mylona EK, Benitez G, Beckwith CG, Chan PA, Mylonakis E
Abstract
OBJECTIVE: To explore the potential association of obesity and other chronic diseases with severe outcomes, such as intensive care unit (ICU) admission and invasive mechanical ventilation (IMV), in patients hospitalized with COVID-19.
METHODS: Retrospective cohort of 103 patients hospitalized with COVID-19. Demographic data, past medical history and hospital course were collected and analyzed. A multivariate logistic regression analysis was implemented to examine associations.
RESULTS: From February 17th to April 5th, 103 consecutive patients were hospitalized with COVID-19. Among them, 41 patients (39.8%) were admitted to the ICU and 29 (70.7%) required (IMV). The prevalence of obesity was 47.5% (49/103). In a multivariate analysis, severe obesity (BMI ≥35 kg/m2) was associated with ICU admission (aOR 5.39; 95% CI:1.13-25.64). Moreover, patients who required IMV, were more likely to have had heart disease (aOR 3.41; 95% CI:1.05-11.06), obesity (BMI=30-34.9 kg/m2) (aOR 6.85; 95% CI: 1.05-44.82) or severe obesity (BMI≥35 kg/m2) (aOR 9.99; 95% CI:1.39-71.69).
CONCLUSION: In our analysis, severe obesity (BMI ≥35 kg/m2) was associated with ICU admission, while history of heart disease and obesity (BMI ≥30 kg/m2) were independently associated with the use of IMV. Increased vigilance and aggressive treatment of patients with obesity and COVID-19 are warranted.
PMID: 32352637 [PubMed - as supplied by publisher]