Is COVID Evolution Due to Occurrence of Pulmonary Vascular Thrombosis?

Link to article at PubMed

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Is COVID Evolution Due to Occurrence of Pulmonary Vascular Thrombosis?

J Thorac Imaging. 2020 Apr 28;:

Authors: Saba L, Sverzellati N

Abstract
In this hypothesis paper, we suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may induce intravascular pulmonary thrombosis, which may result in the rapid worsening of clinical conditions and, eventually, exitus. Previously published papers have demonstrated that increased levels of D-dimer at hospital admission correlate with a more severe disease (0.5 mg/L) or occurrence of death (1 mg/L). The potential prothrombotic action of the SARS-CoV-2 is supported by the topographical involvement of the lung regions with a predilection for the lower lobe with peripheral involvement. If this hypothesis is demonstrated, this could suggest the benefit of using antithrombotic/coagulation regimens for SARS-CoV-2 and, at the same time, the urgency to identify drugs that could alter the inflammatory storm, thus protecting the vessel wall.

PMID: 32349055 [PubMed - as supplied by publisher]

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