Clinical characteristics of non-critically ill patients with novel coronavirus infection (COVID-19) in a Fangcang Hospital.
Clin Microbiol Infect. 2020 Apr 03;:
Authors: Wang X, Fang J, Zhu Y, Chen L, Ding F, Zhou R, Ge L, Wang F, Chen Q, Zhang Y, Zhao Q
OBJECTIVES: Describe the clinical characteristics of patients in Fangcang Hospital.
METHODS: Non-critically ill patients with positive SARS-CoV-2 RT-PCR tests admitted to Dongxihu 'Fangcang' Hospital between February 7th and 12th were included, which was promptly constructed because of the rapid, exponential increase in COVID-19 patients in Wuhan, China; clinical course through February 22nd was recorded.
RESULTS: 1012 non-critically ill patients with positive SARS-CoV-2 RT-PCR tests were included in the study. 30 (of 1012, 3.0%) patients were asymptomatic on admission. During hospitalization, 16 of 30 (53.3%) asymptomatic patients suffered from different symptoms. Fourteen of 1012 patients (1.4%) remained asymptomatic from exposure to the end of follow-up, with a median duration of 24 days (IQR 22-27). Fever (761 of 1012, 75.2%) and cough (531 of 1012, 52.4%) were the most common symptoms. Small patchy opacities (355 of 917, 38.7%)and ground-glass opacities (508 of 917, 55.4%) were common imaging manifestations in chest CT scan. One hundred patients (9.9%) were transferred to designated hospitals due to aggravation of illness. Diarrhea emerged in 152 of 1012 patients (15.0%). Male, elder age, diabetes cardiovascular diseases, chills, dyspnea, SO2 value of ≤93%, WBC counts of >10 ×109/L and large consolidated opacity on CT images were all risk factors for aggravation of illness.
CONCLUSIONS: Non-critically ill patients had different clinical characteristics than critically ill patients. Asymptomatic infections only accounted for a small proportion of COVID-19. Although with a low incidence, diarrhea was observed in patients with COVID-19, indicating the possibility of faecal-oral transmission.
PMID: 32251842 [PubMed - as supplied by publisher]