Impacts of Admission Serum Albumin Levels on Short-Term and Long-Term Mortality in Hospitalized Patients.
QJM. 2019 Nov 20;:
Authors: Thongprayoon C, Cheungpasitporn W, Chewcharat A, Mao MA, Thirunavukkarasu S, Kashani KB
BACKGROUND: The aim of this study is to assess the association between admission serum albumin and short- and long-term mortality in all hospitalized patients.
METHODS: A retrospective cohort of all adult hospitalized patients at a tertiary referral hospital between January 2009 and December 2013 were analyzed. Admission serum albumin was stratified into 6 groups; ≤2.4, 2.5-2.9, 3.0-3.4, 3.5-3.9, 4.0-4.4, and ≥4.5 g/dL. The outcomes of interest were in-hospital mortality, length of hospital stay, and 1-year mortality. Serum albumin of 4-4.4 g/dL was selected as a reference group for outcome comparison.
RESULTS: A total of 14,075 patients were studied. Admission serum albumin of ≥ 4.5 g/dL had the lowest in-hospital and 1-year mortality with progressively increased in-hospital mortality observed with decreased admission serum albumin. In adjusted analysis, compared with serum albumin of 4.0-4.4 g/dL, serum albumin of ≤ 2.4, 2.5-2.9, 3.0-3.4, 3.5-3.9 were significantly associated with increased in-hospital and 1-year mortality. In contrast, serum albumin of ≥ 4.5 g/dL was significantly associated with lower 1-year mortality but not in-hospital mortality. Admission serum albumin <4.0 g/dL was significantly associated with a prolonged hospital stay, while admission serum albumin of ≥ 4.5 g/dL was significantly associated with shorter hospital stay, compared with serum albumin of 4.0-4.4 g/dL.
CONCLUSION: Low albumin level at admission was progressively associated with increased short- and long-term mortality in all hospitalized patients even when albumin level was considered in normal range.
PMID: 31747010 [PubMed - as supplied by publisher]