Potential antigenic mismatch of the H3N2 component of the 2019 Southern Hemisphere influenza vaccine.
Clin Infect Dis. 2019 Aug 11;:
Authors: Gouma S, Weirick M, Hensley SE
Here, we find that the egg-adapted H3N2 component of the 2019 Southern Hemisphere influenza vaccine elicits an antibody response in ferrets that is highly focused on antigenic site A of hemagglutinin. This is potentially problematic since most H3N2 viruses currently circulating in the Southern Hemisphere possess antigenic site A substitutions.
PMID: 31400756 [PubMed - as supplied by publisher]