Ceftaroline as salvage therapy for complicated MRSA bacteremia: case series and analysis.
Infection. 2019 Apr 06;:
Authors: Bhowmick T, Liu C, Imp B, Sharma R, Boruchoff SE
INTRODUCTION: Methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infection (BSI) is a major cause of morbidity and mortality in hospitalized patients. Ceftaroline fosamil (CPT) is the only available beta-lactam antibiotic with in vitro and in vivo activities against MRSA. There is currently limited clinical experience with CPT in complicated MRSA BSI.
MATERIALS AND METHODS: We report a series of eight patients, including three whose strains had reduced susceptibility to vancomycin.
RESULTS: CPT monotherapy was successfully used as salvage therapy for complicated MRSA BSI. The median time to documented clearance was 7 days.
CONCLUSION: Ceftaroline monotherapy is effective for clearance of refractory MRSA BSI related to implanted devices, endocarditis, and orthopedic infections.
PMID: 30955166 [PubMed - as supplied by publisher]