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Prevalence of atrial fibrillation in hospital encounters with end-stage chronic obstructive pulmonary disease on home oxygen: National trends in the United States.
Chest. 2019 Jan 23;:
Authors: Xiao X, Han H, Wu C, He Q, Ruan Y, Zhai Y, Gao Y, Zhao X, He J
Abstract
BACKGROUND: This study aimed to evaluate the prevalence of atrial fibrillation (AF) in hospital encounters with end-stage chronic obstructive pulmonary disease (COPD) on home oxygen admitted for COPD exacerbation.
METHODS: We used the 2003-2014 Nationwide Inpatient Sample to conduct a retrospective analysis. The present study included all patients aged ≥18 years with a primary diagnosis of COPD on home oxygen who were hospitalized for COPD exacerbation. We used multivariate-adjusted models to evaluate the association of AF with clinical factors, cost, length of stay, and hospital outcomes.
RESULTS: In total, 1,345,270 patients were included, of whom 244,488 (18.2%) had AF. The AF prevalence increased from 12.9% in 2003 to 21.3% in 2014 (p<0.0001) and varied by age, sex, race, income, insurance type, and hospital region. Advancing age, female sex, white race, high income, and large hospital size were associated with increased odds of AF. Presence of AF was a risk predictor for in-hospital death (odds ratio [OR]=1.54, 95% confidence interval [CI]:1.45-1.65), acute respiratory failure (OR=1.09, 95% CI:1.06-1.12), invasive mechanical ventilation (OR=1.37, 95% CI:1.29-1.47), non-invasive mechanical ventilation (OR=1.14, 95% CI:1.09-1.18), acute kidney injury (OR=1.09, 95% CI:1.04-1.13), sepsis (OR=1.23, 95% CI:1.10-1.37), and stroke (OR=1.80, 95% CI:1.40-2.32). AF was also associated with increased cost and length of stay.
CONCLUSION: AF prevalence in hospital encounters with end-stage COPD increased from 2003 to 2014. Better management strategies for end-stage COPD patients comorbid with AF are needed, especially in elderly individuals.
PMID: 30684473 [PubMed - as supplied by publisher]