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Probiotic use as prophylaxis for Clostridium difficile-associated diarrhea in a community hospital.
Am J Infect Control. 2019 Jan 18;:
Authors: Hudson SL, Arnoczy G, Gibson H, Thurber C, Lee J, Kessell A
Abstract
This study was a retrospective chart review from January 1, 2015 through June 30, 2017, comparing the incidence of Clostridium difficile-associated diarrhea (CDAD) in patients taking select broad spectrum antibiotics with probiotics versus without probiotics. The purpose was to determine if probiotic use was associated with a reduction in the incidence of CDAD. A total of 5,574 hospital encounters were reviewed, showing a 0.96% incidence of CDAD in patients receiving a probiotic compared to a 2.19% incidence of CDAD in patients with no probiotic (risk ratio = 0.442; P = .00743). These findings show probiotic use was associated with a statistically significant lower incidence of positive C. difficile test results compared to no probiotic use.
PMID: 30665779 [PubMed - as supplied by publisher]