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Hyperuricemia is associated with acute kidney injury and all-cause mortality in hospitalized patients.
Nephrology (Carlton). 2019 Jan 15;:
Authors: Kang MW, Chin HJ, Joo KW, Na KY, Kim S, Han SS
Abstract
BACKGROUND: Hyperuricemia is a risk factor for high morbidity and mortality in several diseases. However, the relationship between uric acid and the risk of acute kidney injury (AKI) and mortality remains unresolved in hospitalized patients.
METHODS: Data from 18,444 hospitalized patients were retrospectively reviewed. The odds ratio (OR) for AKI and the hazard ratio (HR) for all-cause mortality were calculated based on the uric acid quartiles after adjustment for multiple variables. All analyses were performed after stratification by sex.
RESULTS: The fourth quartile group (male, UA > 6.7 mg/dL; female, UA > 5.4 mg/dL) showed a higher risk of AKI compared with the first quartile group (male, UA < 4.5 mg/dL; female, UA < 3.6 mg/dL), with the following ORs: 3.2 (2.55-4.10) in males (P < 0.001); and 3.1 (2.40-4.19) in females (P < 0.001). There were more patients who did not recover from AKI in the fourth quartile compared with the first quartile, with the following ORs: 2.0 (1.32-3.04) in males (P = 0.001) and 2.4 (1.43-3.96) in females (P = 0.001). The fourth quartile group had a higher risk of all-cause mortality compared with the first quartile group, with the following HRs: 1.4 (1.20-1.58) in males (P < 0.001) and 1.2 (1.03-1.46) in females (P = 0.019). The in-hospital mortality risk was also higher in the fourth quartile compared with the first quartile, which was significant only in males [OR, 2.1 (1.33-3.31)(P = 0.002)].
CONCLUSION: Hyperuricemia increases the risks of AKI and all-cause mortality in hospitalized patients. This article is protected by copyright. All rights reserved.
PMID: 30644622 [PubMed - as supplied by publisher]