TUSARC PROGNOSTIC: Prognostic value of high sensitivity troponin T assay in asymptomatic high cardiovascular risk patients.
Am J Med. 2018 Dec 14;:
Authors: Raymondi DM, Garcia H, Álvarez I, Hernández L, Molinero JP, Villamandos V
OBJECTIVES: Prognostic value of high-sensitivity cardiac troponin T assays (hs-cTnT) have been carried out on selected populations in different studies and in registries of low cardiovascular risk general population. The aim of this study is to determine the prognostic value of hs-cTnT in a Spanish asymptomatic very high cardiovascular risk population.
METHOD: From previously prospective cohort of TUSARC (troponina T UltraSensible en pacientes Asintomáticos de alto Riesgo Cardiovascular) registry, follow up was done in 602 patients (93,18%). The association of high hs-cTnT (≥99th percentile value) and incident of primary event was studied. Primary event was defined as combined mayor cardiovascular event (incident of cardiovascular death, decompensated heart failure, non-fatal cerebrovascular event, non-fatal myocardial infarction or coronary revascularization). Association of high hs-cTnT and incident or secondary events was studied as well.
RESULTS: in patients with elevated high hs-cTnT, the incidence of primary event during follow up was significantly higher (18,3% vs 3,67% p< 0,001), as it was the incidence of heart failure (6,25 vs 0,73 p<0,001), CVD (7,29% vs 0% p<0,001), and death from any cause (7,81% vs 0,98% p<0,001).
CONCLUSION: In a Spanish asymptomatic very high cardiovascular risk population elevated HScTT was significantly associated with incident mayor cardiovascular combined end point and incidence of heart failure, cardiovascular death and death from any cause.
PMID: 30557532 [PubMed - as supplied by publisher]