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Progressive Multifocal Leukoencephalopathy.
Neurol Clin. 2018 Nov;36(4):739-750
Authors: Grebenciucova E, Berger JR
Abstract
Progressive multifocal leukoencephalopathy (PML) is a rare opportunistic infection that occurs in patients whose immune system is compromised either because of an underlying illness or an immunosuppressive medication. John Cunningham virus, prevalent in 60% or more of the adult population as a latent or persistent infection, is responsible for the syndrome of PML. This article reviews PML in association with the most common immunotherapies and discusses risk mitigation and monitoring strategies.
PMID: 30366552 [PubMed - in process]