Prion Diseases.

Link to article at PubMed

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Prion Diseases.

Neurol Clin. 2018 Nov;36(4):865-897

Authors: Tee BL, Longoria Ibarrola EM, Geschwind MD

Prions diseases are uniformly fatal neurodegenerative diseases that occur in sporadic, genetic, and acquired forms. Acquired prion diseases, caused by infectious transmission, are least common. Most prion diseases are not infectious, but occur spontaneously through misfolding of normal prion proteins or genetic mutations in the prion protein gene. Although most prion diseases are not caused by infection, they can be transmitted accidentally. Certain infection control protocols should be applied when handling central nervous system and other high-risk tissues. New diagnostic methods are improving premortem and earlier diagnosis. Treatment trials have not shown improved survival, but therapies may be available soon.

PMID: 30366560 [PubMed - in process]

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