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Rational approach in the management of P.aeruginosa infections.
Curr Opin Infect Dis. 2018 Oct 05;:
Authors: Bassetti M, Vena A, Russo A, Croxatto A, Calandra T, Guery B
Abstract
PURPOSE OF REVIEW: This review details the management of P. aeruginosa infections covering both current and future treatment options that are and may be available for the clinicians.
RECENT FINDINGS: P. aeruginosa infections are a great concern in hospital-acquired infections with very limited therapeutic options. The increasing antibiotic resistance has led to a need for different treatment choices that range from the use of new antibiotics to new non-antibiotic alternative agents to kill or disarm the pathogen.
SUMMARY: New molecules such as ceftolozane-tazobactam, ceftazidime-avibactam, and imipenem-relebactam have shown an adequate activity against P. aeruginosa, especially against multidrug resistance strains. Other non-antibiotic alternative treatments, such as antibodies, bacteriocins or phage therapy, have shown promising results, but future clinical studies are needed.
PMID: 30299364 [PubMed - as supplied by publisher]