Prediction of 28-days Mortality with Sequential Organ Failure Assessment (SOFA), quick SOFA (qSOFA) and Systemic Inflammatory Response Syndrome (SIRS) - A Retrospective Study of Medical Patients with Acute Infectious Disease.
Int J Infect Dis. 2018 Sep 26;:
Authors: Gaini S, Relster MM, Pedersen C, Johansen IS
AIMS: Evaluating the use of Sequential Organ Failure Assessment (SOFA) ≥ 2 compared to quick SOFA (qSOFA) and to Systemic Inflammatory Response Syndrome (SIRS) in assessing 28-days mortality in medical patients with acute infection.
METHODS: In total, 323 patients with verified infection were stratified in accordance to Sepsis-3. SOFA, qSOFA and SIRS were calculated using registered variables. Adverse outcome was death within 28-days of admission.
RESULTS: In total, 190 (59%) patients had a SOFA score≥2 and the overall in-hospital mortality was 21 (6%). Scores of SOFA and qSOFA were both significantly elevated in non-survivors. SOFA showed good accuracy (Area under the receiver operating characteristic (AUROC)=0.83, 95% CI, 0.76 - 0.90) for 28-days mortality compared with qSOFA (AUROC=0.67, 95% CI, 0.54 - 0.80) and SIRS (AUROC=0.62, 95% Cl 0.49 - 0.74). SOFA was≥2 in all patients who died, while qSOFA and SIRS was≥2 in 8 (38%) and 17 (81%) of the patients who died, respectively.
CONCLUSION: SOFA score≥2 was better than SIRS and qSOFA to predict mortality within 28-days of admission among patients with acute infectious disease.
PMID: 30267939 [PubMed - as supplied by publisher]