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Results of the modification of an acute pancreatitis management protocol in Intensive Care medicine.
Med Intensiva. 2018 Jul 30;:
Authors: Amas Gómez L, Zubia Olaskoaga F
Abstract
OBJECTIVE: To determine whether the implementation of a protocol for the management of patients with acute pancreatitis (AP) in an Intensive Care Unit (ICU) improves the clinical outcomes.
DESIGN: A retrospective, before-after observational case series study was carried out.
STUDY PERIOD: 1 January 2001 to 31 December 2016, divided in 2 periods (pre-protocol 2001-2007, post-protocol 2008-2016).
SCOPE: An ICU with 48 beds and a recruitment population of 700,000 inhabitants.
PARTICIPANTS: AP patients admitted to the ICU, with no exclusion criteria.
INTERVENTIONS: The recommendations proposed in the 7th Consensus Conference of the SEMICYUC on AP (5 September 2007) were applied in the second period.
MAIN VARIABLES OF INTEREST: Patient age, sex, APACHE II, SOFA, study period, pre-ICU hospital stay, nutrition, surgery, antibiotic prophylaxis, hospital mortality, ICU length of stay, hospital length of stay, determinant-based classification.
RESULTS: The study comprised 286 patients (94 in the pre-protocol period, 192 in the post-protocol period), with a global in-hospital mortality rate of 23.1% (n=66). Application of the protocol decreased the pre-ICU hospital stay and the use of antibiotic prophylaxis, and increased the use of enteral nutrition. Hospital mortality decreased in the second period (35.1 vs. 17.18%; P=.001), with no significant changes in ICU and hospital stays. In the multivariate logistic regression analysis, the variable period of treatment remained as a variable of statistical significance in terms of hospital mortality (OR 0.34 for the period 2008-2016, 95% CI 0.15-0.74).
CONCLUSIONS: The implementation of a protocol could result in decreased mortality among AP patients admitted to the ICU.
PMID: 30072142 [PubMed - as supplied by publisher]