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Iron deficiency and long-term mortality in elderly patients with acute coronary syndrome.
Biomark Med. 2018 Jul 25;:
Authors: González-D'Gregorio J, Miñana G, Núñez J, Núñez E, Ruiz V, García-Blas S, Bonanad C, Mollar A, Valero E, Amiguet M, Sastre C, Sanchis J
Abstract
AIM: We evaluated the relationship between iron deficiency (ID) and long-term mortality risk in elderly patients with acute coronary syndrome (ACS).
METHODS: In this prospective observational study, we included 252 patients older than 65 years with ACS. Transferrin saturation (TSAT) and ferritin were collected before discharge.
RESULTS: Mean age, hemoglobin and GRACE score were 78 ± 7 years, 12.4 ± 1.8 g/dl and 138.8 ± 25.3, respectively, 112(44.4%) patients were women, and 151(59.9%) presented ID. During the follow-up, 121 (48%) patients died. Mortality rates among TSAT quartiles were: 2.38, 1.60, 0.90 and 0.95 × 10 person-years for Q1TSAT to Q4TSAT, respectively (p < 0.001) and did not differ across ferritin quartiles (p = 0.601), whereas ID definition was borderline associated (p = 0.060). Adjusted TSAT levels remained inverse, nonlinearly associated with long-term mortality risk (p < 0.001), with an exponential increased-risk from values about 20% and below.
CONCLUSION: Lower TSAT levels were independently associated with increased mortality risk in these patients.
PMID: 30043644 [PubMed - as supplied by publisher]